What is the purpose of Trastuzumab Injection 440mg?
Trastuzumab Injection 440mg, also known as Herceptin, Herzuma, and Ontruzant, is a cancer medication with a specific target. It is used to treat early and advanced breast cancer, advanced stomach cancer, and cancer of the junction between the food pipe and the stomach (gastro-oesophageal junction).
Is trastuzumab a drug or a pill?
Certain kinds of stomach cancer that have spread to other places of the body are treated with trastuzumab injectable products in combination with other drugs. Trastuzumab belongs to the monoclonal antibody class of drugs. It works by preventing cancer cells from growing.
Is trastuzumab a monoclonal antibody or a polyclonal antibody?
Trastuzumab (Herceptin, Genentech, Inc., South San Francisco, California) is a highly purified humanized monoclonal immunoglobulin G1 kappa antibody that binds to the extracellular domain of the HER2 receptor with great affinity and specificity.
What is trastuzumab’s mechanism of action?
- Trastuzumab Injection 440mg’s Mechanism of Action
- Trastuzumab is made up of two antigen-specific sites that bind to the juxtamembrane part of the HER2 receptor’s extracellular domain and block its intracellular tyrosine kinase from being activated.
- Human IgG with a conserved Fc component makes up the rest of the antibody. For more details Click Here.
What is the efficacy of trastuzumab?
A 2014 study of almost 4000 patients found that adding trastuzumab to chemotherapy increased 10-year survival from 75.2 percent to 84 percent, resulting in a 37 percent relative improvement in overall survival. The disease-free survival rate climbed from 62.2 percent to 73.7 percent over a 10-year period. All patient groupings reaped the benefits.
Is trastuzumab associated with hair loss?
Hair loss is not a common side effect of trastuzumab treatment. If you receive Trastuzumab Injection 440mg with chemotherapy, you may develop hair loss as a side effect of the chemotherapy.
Is bevacizumab a monoclonal antibody or a polyclonal antibody?
Bevacizumab (Avastin) is a humanized monoclonal antibody with two antigen-binding domains that inhibit all active forms of vascular endothelial growth factor-A. It was created as an anticancer agent and is still in use today (for colorectal and non-small cell lung cancers).