Fulvira 250mg Injection

Trade Name: Fulvira

Manufacturer: Abbott

Presentation: Injection

Strength: 250mg

Description:

Fulvira 250mg Injection contains fulvestrant, which is a selective estrogen receptor degrader (SERD). It is mainly used in the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women.

Mechanism of Action:

Fulvestrant works by binding to estrogen receptors and promoting their degradation. This leads to a decrease in estrogen receptor levels in breast cancer cells, which helps prevent their growth. Unlike other hormonal treatments that block estrogen receptors, fulvestrant reduces the number of available receptors, providing a more comprehensive approach to block estrogen signaling in cancer cells.

Indications:

Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women who have disease progression following anti-estrogen therapy.

Dosage and Administration:

The usual dose of Fulvira 250mg Injection is:

  • Initial dose: 500 mg administered intramuscularly on days 1, 15, and 29.
  • Maintenance dose: 500 mg administered once a month thereafter.

The injection is usually administered into the buttocks by a healthcare professional.

Side Effects:

Common side effects of Fulvira 250mg Injection may include:

  • Injection site reactions (pain, swelling, redness)
  • Nausea
  • Fatigue
  • Hot flashes
  • Weakness
  • Bone pain

Severe side effects can include:

  • Allergic reactions
  • Liver dysfunction
  • Blood clotting disorders

Precautions:

  • Patients should inform their healthcare provider about any known allergies, pre-existing conditions, or other medications they are taking.
  • Regular monitoring of liver function tests is recommended.
  • Use with caution in patients with bleeding disorders or those on anticoagulant therapy.

Storage:

Fulvira 250mg Injection should be stored in a refrigerator (2°C to 8°C) and protected from light. Do not freeze.

Conclusion:

Fulvira 250mg Injection (Fulvestrant) is a valuable therapeutic option for postmenopausal women with hormone receptor-positive metastatic breast cancer. Its unique mechanism of reducing estrogen receptors offers an effective approach for patients who have progressed on other anti-estrogen therapies. Proper administration and monitoring are essential to maximize its benefits and manage potential side effects.

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