Oxaliplatin 50mg Injection Oxpla

Trade Name: Oxpla

Manufacturer: Zydus Cadila

Presentation: Injection

Strength: 50mg

What is Oxaliplatin 50 mg used to treat?

Oxaliplatin 50 mg is a drug that is used in combination with other drugs to treat advanced colon or rectal cancer (cancer that begins in the large intestine). Oxaliplatin is also used in combination with other drugs to prevent colon cancer from spreading after surgery to remove the tumour.

How long can you have oxaliplatin for?

Treatment cycles include oxaliplatin and capecitabine chemotherapy. This implies you’ll take the medications and then take some time off to let your body recuperate. Each cycle is three weeks long (21 days). You may have between 4 and 8 cycles, depending on your needs.

Will I lose my hair with oxaliplatin?

It’s possible that you’ll lose all of your hair. This includes your lashes, eyebrows, underarm, leg, and pubic hair, among other things. When the therapy is over, your hair will normally come back, but it will be softer. It may return in a different colour or with a curlier texture than before.

How successful is oxaliplatin?

The addition of oxaliplatin was not related with a significant improvement in the slopes (per half-year) of the three-year disease-free survival rate (0.2 percent, 95 percent CI: 1.72.2 percent) or the five-year overall survival rate (0.6 percent, 95 percent CI: 1.83%).

Can oxaliplatin cause liver damage?

Oxaliplatin-based chemotherapy has been linked to liver damage in an increasing number of studies (1–5). Sinusoidal dilatation, hepatocyte atrophy and/or fibrosis, and venular blockage are histological signs of oxaliplatin-induced liver injury (1,2,4,5).

Can you drink with oxaliplatin?

Avoid cold liquids during the infusion because they can start rapidly. If you have volunteers or assistance in your infusion room who check on patients and bring drinks or snacks, make sure they only bring room temperature or warm liquids to anyone getting Oxaliplatin.

How long should you avoid cold with oxaliplatin?

The same idea, Reiss and her colleagues reasoned, may be utilized to reduce cold sensitivity caused by oxaliplatin therapy. “We usually advise patients to stay away from cold foods for the first three to seven days after treatment.”

What are the long-term side effects of oxaliplatin?

Numbness and tingling in the hands and feet appeared to be the side effects that lasted the longest in those who were given oxaliplatin. During therapy, the FLOX group had a considerably higher risk of hand numbness/tingling, which was no longer significant at 18 months but was still significant at the long-term endpoint.

Does oxaliplatin cause weight gain?

Swelling and redness at the injection site of the drug. Damage to the liver can cause yellowing of the eyes and skin. Kidney damage may necessitate dialysis. Dehydration, weight gain, and weight reduction.

Can Oxaliplatin 50 mg cause kidney failure?

Conclusions: Oxaliplatin can cause renal tubular vacuolization, acute tubular necrosis, renal tubular acidosis, and acute kidney injury secondary to haematological toxicity, among other things.

Is oxaliplatin cumulative?

Unlike cisplatin, which rapidly accumulates in plasma as both free and bound platinum, oxaliplatin does not collect in plasma but does accumulate in RBCs after multiple cycles at the current recommended dose (130 mg/m2) and administration schedule (every 3 weeks).

How is oxaliplatin metabolised?

Oxaliplatin undergoes substantial nonenzymatic biotransformation and is not metabolised by the CYP450 enzyme. In plasma ultrafiltrate samples from patients, up to 17 platinum-containing compounds have been discovered. To know more click here.

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