Nalbuphine HCl Injection 10mg Rubuphine

Nalbuphine HCl injections are used to treat moderate to severe pain. They can also be administered before and after surgery or in conjunction with general anesthesia. Additionally, they can be used to lessen pain during childbirth. Nalbuphine is a member of the class of drugs known as narcotic analgesics (pain medicines).

The drug nalbuphine injection belongs to the group of drugs known as opioid agonist-antagonists. It functions by altering how the body perceives pain.

There are nalbuphine uses that are not FDA-approved, including the management of labor pain, the treatment of opioid-induced urine retention, the treatment of opioid-induced respiratory depression, and the treatment of opioid-induced pruritus.

• Drowsiness
• dizziness
• a spinning sensation
• dry mouth
• headaches
• sweating
• cold, clammy skin
• nausea and vomiting are examples of common adverse effects.

Nalbuphine has a 5-hour plasma half-life, and clinical investigations have shown that the analgesic effect lasts between 3 and 6 hours.

A synthetic opioid agonist-antagonist is what nalbuphine hydrochloride (Nubain®) is categorized as. It shares chemical similarities with both the strong opioid agonist oxymorphone and the opioid antagonist naloxone. 17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6-14-triol hydrochloride is the chemical name for nalbuphine.

When combined with other opioids or CNS depressants, NUBAIN use has the potential to cause serious, deadly, or life-threatening respiratory depression. Keep an eye out for respiratory depression, especially first starting NUBAIN or after increasing the dose [see WARNINGS].

Paracetamol is a topical pain reliever used to treat aches and pains. It can also lower a high temperature. Paracetamol is offered in combination with other narcotics and anti-sickness medications. It is also a component of many different antiviral medications.

When considering the entire analgesic impact, which takes into account both the length and the degree of the analgesia, oral nalbuphine is 1/4 to 1/5 as potent as injectable nalbuphine. However, oral nalbuphine is only 1/100 as strong in terms of peak effect.

Conclusions. Nalbuphine HCl ER tablets show potential in the treatment of uremic pruritus and can be safely delivered to HD patients without dose adjustment up to 240 mg BID.

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