What is the best way to administer a Gemcitabine injection of 1400mg?
Gemcitabine injection 1400mg is available as a powder that must be combined with fluids and injected intravenously (into a vein) by a doctor or nurse in a medical institution over the course of 30 minutes. Gemcitabine is frequently given on specific days every three weeks to treat ovarian or breast cancer.
Who came up with the idea for gemcitabine?
History. In the early 1980s, Larry Hertel’s group at Eli Lilly and Company produced gemcitabine for the first time. Although it was designed to be an antiviral, preclinical studies revealed that it destroyed leukemia cells in vitro. Gemcitabine was explored in clinical studies in the early 1990s.
What are the negative effects of chemotherapy with Gemcitabine injection 1400mg?
- For people receiving Gemcitabine, the following adverse effects are common (occurring in more than 30% of cases):
- Symptoms of the flu (muscle pain, fever, headache, chills, fatigue)
- It’s a fever (within 6-12 hours of the first dose)
- nauseous (mild)
- Low blood platelets
- Appetite problems.
- A rash on the skin.
- Blood counts are low.
What is the efficacy of gemcitabine?
For patients with unresectable locally advanced or metastatic pancreatic cancer, Gemcitabine injection 1400mg therapy has been the conventional first-line treatment since 1997. The 5-year survival rate for patients with metastatic disease is only 2%,1 while 1-year survival rates of 17 to 23% have been recorded with gemcitabine. Read more
How does gemcitabine get rid of itself?
The main metabolite of Gemcitabine injection 1400mg, 2′,2′-difluoro-deoxyuridine (dFdU), is rapidly and extensively inactivated by cytidine deaminase (CDA); CDA is expressed ubiquitously at high levels in both plasma and the liver.
Is gemcitabine a drug that weakens the immune system?
Gemcitabine injection 1400mg produces a significant reduction in lymphocytes, according to this study. It suppresses the humoral immune response while sparing antigen-specific cellular immunity.
When you take gemcitabine, how long does it last in your system?
The chemotherapy remains in the body for 2 to 3 days after treatment, however, patients may develop short- and long-term side effects. Although not all patients may suffer all of the negative effects, many wills.