Gefitinib Tablet 250mg Gefitec

What is the Gefitinib Tablet 250mg used for?

Lung cancer is treated with Gefitinib Tablet 250mg works by delaying or stopping the multiplication of cancer cells. Gefitinib inhibits the activity of a certain protein (an enzyme called tyrosine kinase).

What are the gefitinib side effects?

• Consequences
• Tenderness or pain in the abdomen or stomach.
• Stools are made of clay.
• diminished desire to eat
• Severe diarrhea
• Itching or a rash on the skin.
• a feeling of nausea and vomiting
• Swelling of the feet or lower legs is a common ailment.
• Eyes or skin that is yellow. For more details Click Here.

What is the best time to take Gefitinib Tablet 250mg?

In persons with certain types of malignancies, Gefitinib Tablet 250mg is used to treat non-small cell lung cancer that has progressed to other regions of the body. Gefitinib belongs to the kinase inhibitor class of drugs.

Is it true that gefitinib causes itching?

In patients on EGFR inhibitors, dry skin is very prevalent; vaginal dryness and itching, perineal dryness, and blepharitis have all been described (15).

Why was gefitinib taken off the market?

Gefitinib Tablet 250mg was on the market from 2003 to 2012, when it was withdrawn due to an inability to demonstrate clinical benefit in multiple randomized trials that did not restrict eligibility based on mechanism of action; that is, eligibility was not limited to patients with NSCLC who had a known EGFR “activating” mutation.

Is the drug gefitinib still in use?

Gefitinib Tablet 250mg was well tolerated by the patients. Skin rashes and diarrhea were the most common side effects. However, larger clinical trials failed to show that gefitinib improved lung cancer patients’ overall survival, and the FDA revoked permission in 2005. In Europe and Asia, gefitinib is still utilized.

Is gefitinib considered a prodrug?

The polyamine analog Gefitec(PPG) prodrug was created by cleaving a disulfide linker between a tumor-targeting ligand polyamine analog (PA) and an epidermal growth factor receptor tyrosine kinase inhibitor Gefitinib.

Gefitinib is a monoclonal antibody, right?

Gefitec(Tarceva) and gefitinib (Iressa) are small-molecule TK inhibitors, whereas cetuximab (Erbitux) is a mouse/human chimeric monoclonal antibody that targets the ligand-binding region of the EGFR.

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