Darunavir and Ritonavir Tablets

Trade name: Durart-R

Manufacturer: Mylan

Presentation :Tablets

Strength :400mg50mg

 What are Darunavir and Ritonavir Tablets used for?

Darunavir and Ritonavir Tablets is a drug that is used in combination with ritonavir (Norvir) and other drugs to treat HIV infection in adults and children aged 3 years and up. Protease inhibitors, such as darunavir, are a type of medicine. It works by lowering HIV levels in the blood.

Why is ritonavir combined with darunavir?

Dolutegravir (DTG) in combination with Durart-R) is a straightforward combination of medications that has the highest genetic barrier to HIV-1 resistance and may be suitable for salvage therapy in some cases.

What are Durart-R tablets used for?

To treat human immunodeficiency virus (HIV) infection, lopinavir and Durart-R are combined with additional drugs. Protease inhibitors, such as lopinavir and ritonavir, are a type of medicine. They work by reducing the amount of HIV in the bloodstream. To know more click here

What is Durart-R cobicistat used for?

Durart-R cobicistat, emtricitabine, and tenofovir are used to treat HIV infection in adults and children weighing at least 88 pounds (40 kg) who have not been treated with other HIV drugs or to replace current medication therapy in select patients already taking HIV medication.

Why is Durart-R used as a booster?

The medicine, on the other hand, is suggested as a supplement to existing protease inhibitors. This is because ritonavir prevents the CYP3A4 pathway in the liver from metabolizing other protease inhibitors. As a result, these medications have larger blood concentrations and are cleared from the body at a slower rate.

What is the mechanism of action of Durart-R?

Durart-R binds to the active site of the protease and prevents it from working. This inhibitor stops the viral polyproteins from being cleaved, preventing the generation of immature, non-infectious viral particles. Protease inhibitors are typically always taken with at least two additional anti-HIV medications.

Does Durart-R cause weight gain?

Durart-R was associated with a statistically significant increase in body weight. Another interesting observation is that patients on TAF regimens acquire more weight as compared to patients on TDF regimens, which is consistent with the findings of a large South African clinical trial.

What are the side effects of Durart-R?

Durart-R has the potential to induce adverse effects. If any of the following symptoms are severe or do not go away on their own, contact your doctor:

  • headache,
  • Diarrhea,
  • vomiting,
  • stomach pain,
  • constipation are all possible symptoms.

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