Colistimethate Sodium 2 MIU Powder

Injections of Colistimethate Sodium are used to treat some bacterial illnesses. The drug colistimethate injection belongs to the category of drugs known as antibiotics. It eliminates bacteria to operate. Colds, the flu, and other viral diseases cannot be treated with antibiotics like colistimethate injection.

A polymyxin antibiotic, colistimethate. Initially, it was believed that colistimethate sodium was less toxic than polymyxin B, but if the two medications are given at equivalent levels, their toxicities may be similar.

Acinetobacter, Citrobacter, E. coli, Enterobacter, H. influenzae, Klebsiella, Morganella morganii, P. aeruginosa, Salmonella, Shigella, and a variety of Stenotrophomonas strains are just a few of the aerobic gram-negative bacteria that colistin is quite effective against.

• Dizziness is one of the most frequent colistin adverse effects. Burning, prickling,
• tingling, and numbness, especially in the tongue and extremities.
• The following are additional effects of colistin:
• Unsteady speaking.
• spinning feeling (vertigo)
• Seizures.
• significant allergic response (anaphylaxis)

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Colistimethate is administered intravenously (IV) or as an injection into a muscle. The usage of injections at home may be demonstrated to you. If you are unsure of how to administer the injection or how to properly discard the discarded IV tubing, needles, and other supplies, refrain from administering the medication to yourself.

The two different polymyxin antibiotics are Colistin (also called Polymyxin E or Colistimethate) and Polymyxin B. A prodrug is colostine (Colistimethate sodium). Colistin basic activity or international units (IU) of prodrug may be written on the product vials’ labels (CBA).

It can take 2 to 3 days to reach adequate colistin concentrations without a loading dose due to the slow conversion rate of the prodrug (CMS) to the active drug (colistin) and the lengthy half-life of colistin (roughly 14.4 hours); the administration of a loading dose may shorten the time to reach the target.

Add 2 mL of sterile water for injection to a vial marked “150 mg of colistin” to reconstitute colistimethate sterile powder; gently swirl to prevent foaming. The final product has a colistin concentration of 75 mg per mL. Half of the daily dosage should be reconstituted and added to a suitable IV solution.

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