Darunavir and Ritonavir Virem R Tablets
Trade name: Virem R
What are darunavir and ritonavir tablets used for?
darunavir and ritonavir is a drug that is used in combination with ritonavir (Norvir) and other drugs to treat HIV infection in adults and children aged 3 and up. Darunavir belongs to a class of drugs known as protease inhibitors. It works by lowering HIV levels in the bloodstream.
Why is ritonavir combined with darunavir?
The ritonavir ‘boosting’ dose serves as a CYP3A inhibitor, enhancing darunavir bioavailability. When darunavir is used with other medicines that are CYP3A inducers or inhibitors, or function as substrates for CYP3A, drug interactions might occur.
What are Virem R tablets used for?
To treat human immunodeficiency virus (HIV) infection, virem r is combined with additional drugs. Protease inhibitors, such as lopinavir and ritonavir, are a type of medicine. They operate by lowering HIV levels in the bloodstream. To know more click here
Is Virem R a sulfa drug?
Virem R had decreased incidences of nausea, diarrhea, and lipid abnormalities when compared to Kaletra. This is a sulfa-containing medicine that should be avoided by anyone who has a known sulfa allergy.
Does Virem R have side effects?
- stomach discomfort,
changes in taste, tingling numbness of the mouth region may occur.
Tell your doctor or pharmacist right away if any of these side effects persist or worsen.
Why is Virem R used as a booster?
The medicine is, however, advised as a supplement to other protease inhibitors. This is because ritonavir prevents other protease inhibitors from being metabolized through the CYP3A4 route in the liver. As a result, these medications have larger blood concentrations and are cleared from the body more slowly.
Is ritonavir an enzyme inducer or inhibitor?
When ritonavir is administered to HIV patients, it inhibits the protease activity of the virus while simultaneously inhibiting the activity of cytochrome P4503A4 (CYP3A4), a drug-metabolizing enzyme that is important in the body’s drug metabolism. Ritonavir improves clinical efficacy by increasing plasma concentrations of other anti-HIV medicines oxidized by CYP3A4, which is accomplished by blocking this enzyme.
Does darunavir cause weight gain?
Darunavir was associated with a statistically significant increase in body weight. Another interesting observation is that patients on TAF regimens acquire more weight as compared to patients on TDF regimens, which is consistent with the findings of a large South African clinical trial.
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