What is the purpose of Dacarbazine Injection?
Dacarbazine Injection belongs to a class of drugs known as alkylating agents. It is used to treat lymphoma and malignant melanoma cancers (a type of skin cancer). It may also be used to treat other types of cancer, depending on your doctor’s recommendation.
What is the role of dacarbazine in cancer treatment?
Dacarbazine is an alkylating agent, which is a type of chemotherapy medication. It acts by adhering to and destroying the cancer cell’s DNA. The genetic code that governs everything a cell does is DNA. The cancer cell cannot split into two new cells if the DNA is broken.
A dacarbazine infusion lasts for how long?
Dacarbazine can be given as a short-term infusion (over 15–30 minutes) as an alternative to an intravenous bolus injection.
What are the negative effects of Dacarbazine Injection?
- Side effects from dacarbazine are possible. Assuming that any of these side effects are serious or don’t disappear, contact your primary care
- a lack of appetite
- mouth and throat irritation
- hair thinning
- On the face, there is a burning or tingling sensation.
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What drug class does Dacarbazine Injection belong to?
Purine analogs are a type of drug that includes dacarbazine. It works by reducing or preventing cancer cell development in the body.
Is Dacarbazine Injection a medication?
Dacarbazine is administered as an intravenous infusion. A healthcare provider will administer this injection to you. Avoid eating anything for 4 to 6 hours before your injection to help prevent severe nausea or vomiting.
Is Dacarbazine Injection able to pass the blood-brain barrier?
Dacarbazine (DTIC) has a 21 percent reaction rate on visceral localizations, but it does not pass the blood-brain barrier (BBB). Biological response modifiers like Interleukin 2 (Il2), which leads to a 25% response rate in disseminated melanoma, don’t work either.
What is the mechanism of Dacarbazine action?
The specific mechanism of dacarbazine’s effect is unknown. Its main mechanism of action is alkylation. Dacarbazine is converted to 5-(3-monomethyl-1-triazolyl)-1H-imidazole-4-carboxamide by liver microsomal enzymes (MTIC). Generating carbonium ions prevents DNA and RNA synthesis.
Is capillary leak syndrome caused by Dacarbazine?
Response rates of 10–21% have been reported with high-dose interleukin-2 (IL-2) or interferon alpha-immunotherapy. Hypotension, capillary leak syndrome, sepsis, and renal failure are all toxicities.
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