What is Bortezomib Injection 3.5 mg used for?
Bortezomib Injection 3.5 mg is a drug that is used to treat multiple myeloma (a type of cancer of the bone marrow). It is also used to treat mantle cell lymphoma patients (fast-growing cancer that begins in the cells of the immune system). It belongs to the antineoplastic agent class of drugs.
Is bortezomib a chemotherapy drug?
Bortezomib is a proteasome inhibitor, which is a type of cancer treatment medicine. Cells contain proteasomes. They assist in the breakdown of proteins that the cell does not require. Bortezomib inhibits the proteasomes, causing proteins to accumulate inside the cell.
How do you use bortezomib injection?
Bortezomib 1 mg powder for solution for injection is given intravenously twice weekly for two weeks at a dose of 1.3 mg/m2 body surface area on days 1, 4, 8, and 11 of a 21-day treatment cycle. A treatment cycle is defined as a three-week period.
How do you dilute bortezomib injection?
2.5 mg/ml Bortezomib After diluting the Solution for Injection to 1 mg/ml (see section 6.6), it is given as a 3-5 second bolus intravenous injection by a peripheral or central intravenous catheter, followed by a flush with sodium chloride 9 mg/ml (0.9 percent) solution for injection.
Does bortezomib cause hair loss?
Hair loss is a common occurrence. Hair loss isn’t a direct side effect of Velcade, but it could be caused by other medications you’re taking with it. People using Velcade plus the cytotoxic medication cyclophosphamide, for example, may experience hair loss. (Cytotoxic medications cause cells to die.)
What are the side effects of bortezomib?
The injection site may cause
lack of appetite,
vomiting and diarrhoea are all common side effects.In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, or diarrhoea.
Is bortezomib oral?
Because bortezomib is supplied parenterally, the new medicine provides the convenience of oral administration. Initially, it was only accessible as an intravenous infusion, but it is now also available as a subcutaneous formulation. To know more click here.
How long is bortezomib in the system?
After a single dose, bortezomib is rapidly transported into tissues, with an initial plasma distribution half-life of fewer than 10 minutes and a terminal elimination half-life of more than 40 hours.
Is bortezomib chemotherapy or immunotherapy?
Bortezomib was the first proteasome inhibitor to be approved for patients who had already received two forms of chemotherapy and whose cancer had advanced despite the most recent treatment.
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