What is Asparaginase 10000IU Injection used for?
To treat acute lymphocytic leukaemia, Asparaginase 10000IU Injection erwinia chrysanthemi is used with other chemotherapy drugs (ALL; a type of cancer of the white blood cells).
How do you give L asparaginase?
Asparaginase is administered as a shot into a big muscle (intramuscular or IM). The medication may need to be divided into two injections, depending on your dose. As an infusion, it can also be delivered into the vein (intravenous or IV). Because this procedure carries a higher risk of an allergic reaction, a test dose is usually administered first.
What is the mechanism of action of asparaginase?
Asparaginase Erwinia chrysanthemi is an anticancer drug made from an asparaginase-specific enzyme produced from Erwinia chrysanthemi. It acts by diminishing the reserves of asparagine, an essential amino acid involved in DNA synthesis and cell survival in malignant cells, resulting in cell death.
What kind of enzyme is asparaginase?
The enzyme l-asparaginase (EC 3.5. 1.1) catalyzes the hydrolysis of asparagine into l-aspartic acid and ammonium. This enzyme is found in a variety of organisms, including bacteria, plants, and some animals, including the serum of some rodents, but it is not found in humans.
How fast does L-asparaginase work?
The average response time was 21 days. The median time it took for a patient to progress was 63 days (111 days for dogs achieving a complete response and 42 days for dogs achieving a partial response).
How often is asparaginase given?
According to published research, Erwinia asparaginase should be given three times weekly at a dose of at least 20,000 IU/m2 by IV or IM.
Where is asparaginase found?
Asparaginase is a commonly utilized enzyme in the pharmaceutical and food sectors. Asparaginase is mostly produced by E. coli, with spectrila being a novel recombinant version of the enzyme.
Is asparaginase vegetarian?
Because asparaginase is eliminated during cooking, it is assumed that it has no effect on food or individuals who consume it.
Is asparaginase found in humans?
The asparaginase activity of human ASPG was biochemically characterized, and it was discovered that it has a low affinity for L-asparagine (Km in the millimolar range), whereas bacterial enzymes that are often utilized as anticancer medicines have a higher affinity for the substrate.
Is asparaginase in asparagus?
Asparagine is an amino acid, which is a type of protein building block. While asparagine can be produced by the body, it is also found in our diet, with larger quantities in some foods such as asparagus. To know more click here.
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